Chronic stress is physiologically dangerous, but it’s particularly damaging to the skin. The skin is the largest organ of the body, protecting us from and interacting with our environment. It doesn’t just shield, it also interacts. Not only is the skin a component of the peripheral HPA axis that communicates with the HPA axis, but it is also a neuroendocrine system that responds to environmental stressors and maintains homeostasis.

Since steroid hormones were isolated by researchers working for an early version of Pfizer (the Canadian pharmaceutical company Ayerst, which became Wyeth, which became Pfizer funded this research) women have been told that both mental and physical health issues would be improved by taking steroid hormones.

Cortisol regulates metabolism. It was named a glucocorticoid hormone in 1954 when they figured out it regulated blood sugar. But cortisol doesn’t just regulate how we metabolize carbohydrates. As part of the adrenal stress response, it also controls how we metabolize protein and fat. The energy to run has to come from everywhere.

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